New insights into the role of non-coding RNAs as transcriptional targets of p53
نویسندگان
چکیده
1Department of Biochemistry, Faculty of Medicine, ”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania 2Research Center for Advanced Medicine, Medfuture, ”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania 3Research Center for Functional Genomics Biomedicine and Translational Medicine, ”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania 4Department of Functional Genomics, Proteomics and Experimental Pathology, Th e Oncology Institute Prof. Dr. Ion Chiricuta, Cluj-Napoca, Romania
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Long non-coding RNAs and their significance in human diseases
Protein-coding genes account for only a small fraction of the human genome and most of the genomic sequences are transcriptionally silent, but recent observations indicate significant functional elements, including non-coding protein transcripts in the human genome. Long non-coding RNAs (lncRNAs) have been defined as transcripts of >200 nucleotides without protein-coding capacity that perform t...
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